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Tg(Cck-cre,-lacZ)1Mini
Transgene Detail
Summary
Symbol: Tg(Cck-cre,-lacZ)1Mini
Name: transgene insertion 1, Liliana Minichiello
MGI ID: MGI:5574585
Synonyms: BAC-Cck-Cre, Cck-cre
Transgene: Tg(Cck-cre,-lacZ)1Mini  Location: unknown  
Alliance: Tg(Cck-cre,-lacZ)1Mini page
Transgene
origin
Strain of Origin:  (CBA x C57BL/6)
Transgene
description
Transgene Type:    Transgenic (Recombinase, Reporter)
Mutation:    Insertion
 
Tg(Cck-cre,-lacZ)1Mini expression driven by 1 gene
 
Mutation detailsA BAC (RP23-26B6) containing the Cck gene was modified by ET recombination so that a cassette composed of a hybrid intron, a cre recombinase gene, an internal ribosomal entry site (IRES), a beta-galactosidase gene (lacZ), and a neomycin/kanamycin resistance marker was inserted into the first ATG of the first coding exon (exon 2). The neo/kan marker was removed using flp recombinase. The purified construct was injected into the pronuclei of (CBA x C57BL/6) hybrid oocytes. (J:210229)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cck (mouse)
Summary of all recombinase alleles driven by Cck.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:210229 Geibel M, et al., Ablation of TrkB signalling in CCK neurons results in hypercortisolism and obesity. Nat Commun. 2014;5:3427
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory