Rr27^tm7.1Msb
Targeted Allele Detail

Summary

• Symbol: Rr27^tm7.1Msb
• Name: regulatory region 27; targeted mutation 7.1, Marisa S Bartolomei
• MGI ID: MGI:5575358
• Synonyms: H19^ICRdelta2,3
• Gene: Rr27 Location: unknown Genetic Position: Chr7, Syntenic
• Alliance: Rr27^tm7.1Msb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211399
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutation: Intergenic deletion
• Mutation details: A 1.3 kb deletion was generated between CTCF sites 1 and 4 and a floxed neomycin resistance gene cassette was inserted downstream of the deletion. The resistance cassette was subsequently removed by cre excision. (J:211399)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rr27 Mutation: 7 strains or lines available

References

• Original: J:211399 Ideraabdullah FY, et al., Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region. Hum Mol Genet. 2014 Dec 1;23(23):6246-59
• All: 1 reference(s)