Primpol^tm1.2Ado
Targeted Allele Detail

Summary

• Symbol: Primpol^tm1.2Ado
• Name: primase and polymerase (DNA-directed); targeted mutation 1.2, Aidan J Doherty
• MGI ID: MGI:5575391
• Gene: Primpol Location: Chr8:47028629-47070247 bp, - strand Genetic Position: Chr8, 26.39 cM
• Alliance: Primpol^tm1.2Ado page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206155
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: An FRT flanked lacZ/neo construct along with a loxP site was inserted upstream of exon 5 and a second loxP site was left in place 3' of exon 5. The 5' selection cassette was then removed by flp recombinase expression leaving exon 5 flanked by loxP sites. Subsequent cre expression excised exon 5. (J:206155)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Primpol Mutation: 48 strains or lines available

References

• Original: J:206155 Bianchi J, et al., PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replication. Mol Cell. 2013 Nov 21;52(4):566-73
• All: 1 reference(s)