Themis^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Themis^m1Btlr
• Name: thymocyte selection associated; mutation 1, Bruce Beutler
• MGI ID: MGI:5575394
• Synonyms: currant
• Gene: Themis Location: Chr10:28544356-28759814 bp, + strand Genetic Position: Chr10, 16.06 cM
• Alliance: Themis^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced an A to G transition at base pair 28,782,011 (v38) on chromosome 10, or base pair 113,685 in the GenBank genomic region NC_000076. The mutation results in an arginine (R) to glycine (G) substitution at position 345 (R345G) and is strongly predicted by Polyphen-2 to cause loss of function (score = 1.00). (J:211400)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Themis Mutation: 57 strains or lines available

References

• Original: J:211400 Wang KW, et al., Direct data submission for currant. MGI Direct Data Submission. 2014
• All: 1 reference(s)