Phox2b^tm1Rth
Targeted Allele Detail

Summary

• Symbol: Phox2b^tm1Rth
• Name: paired-like homeobox 2b; targeted mutation 1, David H Rowitch
• MGI ID: MGI:5575410
• Gene: Phox2b Location: Chr5:67251751-67256399 bp, - strand Genetic Position: Chr5, 35.95 cM
• Alliance: Phox2b^tm1Rth page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Reporter)
• Mutation: Insertion
• Mutation details: Exon 3 of the mouse Phox2b gene was flanked by loxP sites. An FRT-flanked neomycin cassette, human exon 3 (modified with an 8 bp deletion, GGCCCGGG) and associated with an EGFP reporter, was inserted downstream. Flp-mediated recombination removed the selection cassette. (J:101977)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Phox2b Mutation: 25 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 4 reference(s)