n-TRtct5^m1J
Spontaneous Allele Detail

Summary

• Symbol: n-TRtct5^m1J
• Name: nuclear encoded tRNA arginine 5 (anticodon TCT); mutation 1, Jackson
• MGI ID: MGI:5575489
• Synonyms: n-Tr20^C57BL/6J, n-TRtct5^rs4644711-T, rs46447118
• Gene: n-TRtct5 Location: Chr1:173217895-173217968 bp, + strand Genetic Position: Chr1, Syntenic
• Alliance: n-TRtct5^m1J page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Spontaneous (Not Specified)
• Mutation: Single point mutation
• Mutation details: This C-to-T transition, the T variant of SNP rs46447118, found in C57BL/6J and C57BL/6JEiJ but not any of the other 18 inbred strains tested, is in nucleotide 50 in the stem of the T loop and impairs maturation, leading to accumulation of a 105 nucleotide pre-tRNA band with leader and trailer sequences instead of the usual 115 nucleotide pre-tRNA, and also diminishes aminoacylation of this isodecoder. (J:211326)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any n-TRtct5 Mutation: 4 strains or lines available

References

• Original: J:211326 Ishimura R, et al., RNA function. Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration. Science. 2014 Jul 25;345(6195):455-9
• All: 17 reference(s)