Gtpbp2^tm1Ynim
Targeted Allele Detail

Summary

• Symbol: Gtpbp2^tm1Ynim
• Name: GTP binding protein 2; targeted mutation 1, Yasuharu Nishimura
• MGI ID: MGI:5575491
• Gene: Gtpbp2 Location: Chr17:46471958-46480296 bp, + strand Genetic Position: Chr17, 22.89 cM, cytoband C-D
• Alliance: Gtpbp2^tm1Ynim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211326
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.6 kb genomic region containing exons 4, 5, and part of exon 6 was replaced by a neomycin selection cassette (J:211326)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gtpbp2 Mutation: 38 strains or lines available

References

• Original: J:211326 Ishimura R, et al., RNA function. Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration. Science. 2014 Jul 25;345(6195):455-9
• All: 1 reference(s)