Ncor2^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Ncor2^tm1.1Ics
• Name: nuclear receptor co-repressor 2; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:5575500
• Synonyms: SMRT^f
• Gene: Ncor2 Location: Chr5:125094217-125256283 bp, - strand Genetic Position: Chr5, 63.96 cM, cytoband F
• Alliance: Ncor2^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206152
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: One loxP site was inserted in intron 3 while a neo resistance cassette flanked with both loxP and an FRT sites (in that order) was inserted in intron 4. The resistance cassette was subsequently removed by expression of flp recombinase leaving exon 4 flanked by loxP sites. (J:206152)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ncor2 Mutation: 170 strains or lines available

References

• Original: J:206152 Sun Z, et al., Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor. Mol Cell. 2013 Dec 26;52(6):769-82
• All: 3 reference(s)