Gins4^tm1Ntak
Targeted Allele Detail

Summary

• Symbol: Gins4^tm1Ntak
• Name: GINS complex subunit 4; targeted mutation 1, Nobuyuki Takakura
• MGI ID: MGI:5575557
• Synonyms: SLD5^-
• Gene: Gins4 Location: Chr8:23716632-23727675 bp, - strand Genetic Position: Chr8, 11.42 cM, cytoband A3
• Alliance: Gins4^tm1Ntak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209708
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A lacZ-neo cassette was inserted to replace exons 2 through upstream of exon 5. Quantitative RT-PCR detected a 50% reduction in expression in testes from heterozygous mice. (J:209708)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gins4 Mutation: 14 strains or lines available

References

• Original: J:209708 Mohri T, et al., Requirement of SLD5 for early embryogenesis. PLoS One. 2013;8(11):e78961
• All: 2 reference(s)