Pld1^tm3Mafr
Targeted Allele Detail

Summary

• Symbol: Pld1^tm3Mafr
• Name: phospholipase D1; targeted mutation 3, Michael Frohman
• MGI ID: MGI:5575654
• Synonyms: Pld1^-
• Gene: Pld1 Location: Chr3:27992844-28187511 bp, + strand Genetic Position: Chr3, 11.15 cM
• Alliance: Pld1^tm3Mafr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211547
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was replaced with an IRES, lacZ reporter and neomycin resistance cassette. Western blot analysis confirmed the absence of protein expression in platelets and the liver. (J:211547)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pld1 Mutation: 64 strains or lines available

References

• Original: J:211547 Elvers M, et al., Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1. Sci Signal. 2010;3(103):ra1
• All: 9 reference(s)