Asxl1^tm1.1Iaai
Targeted Allele Detail

Summary

• Symbol: Asxl1^tm1.1Iaai
• Name: ASXL transcriptional regulator 1; targeted mutation 1.1, Iannis Aifantis
• MGI ID: MGI:5575656
• Synonyms: Asxl1^fl
• Gene: Asxl1 Location: Chr2:153187750-153245927 bp, + strand Genetic Position: Chr2, 75.41 cM
• Alliance: Asxl1^tm1.1Iaai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208092
• Parent Cell Line: BAC-BA1 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S/SvEv)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Two loxP sites flanking exon 5-10 and an Frt-flanked neomycin selection cassette were inserted in the upstream intron. Flp-mediated recombination removed the neomycin cassette and left exons 5-10 floxed. (J:208092)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Asxl1 Mutation: 116 strains or lines available

References

• Original: J:208092 Abdel-Wahab O, et al., Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo. J Exp Med. 2013 Nov 18;210(12):2641-59
• All: 7 reference(s)