Asxl1^tm1.1Mjxu
Targeted Allele Detail

Summary

• Symbol: Asxl1^tm1.1Mjxu
• Name: ASXL transcriptional regulator 1; targeted mutation 1.1, Mingjiang Xu
• MGI ID: MGI:5575668
• Synonyms: Asxl1:nlacZ/nGFP
• Gene: Asxl1 Location: Chr2:153187750-153245927 bp, + strand Genetic Position: Chr2, 75.41 cM
• Alliance: Asxl1^tm1.1Mjxu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208085
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 1 was replaced with a loxP site, nuclear localized lacZ reporter, loxP site, nuclear localized GFP (H2B-GFP) reporter and FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. Western blot analysis confirmed the absence of protein expression in bone marrow cells. (J:208085)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Asxl1 Mutation: 116 strains or lines available

References

• Original: J:208085 Wang J, et al., Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice. Blood. 2014 Jan 23;123(4):541-53
• All: 5 reference(s)