Mir1a-2^tm1Dsr
Targeted Allele Detail

Summary

• Symbol: Mir1a-2^tm1Dsr
• Name: microRNA 1a-2; targeted mutation 1, Deepak Srivastava
• MGI ID: MGI:5575740
• Gene: Mir1a-2 Location: Chr18:10785481-10785552 bp, - strand Genetic Position: Chr18, 5.4 cM
• Alliance: Mir1a-2^tm1Dsr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211548
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence for the mature 21 nt sequence was replaced by a neomycin/lacZ construct leaving the rest of the transcript sequence intact. Absence of transcript for the deleted 21 nt was confirmed by PCR. A neighboring miRNA and the gene in which the two micro RNAs are "embedded" are both transcribed normally. (J:211548)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir1a-2 Mutation: 0 strains or lines available

References

• Original: J:211548 Zhao Y, et al., Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell. 2007 Apr 20;129(2):303-17
• All: 4 reference(s)