Mir1a-1^tm1Dsr
Targeted Allele Detail

Summary

• Symbol: Mir1a-1^tm1Dsr
• Name: microRNA 1a-1; targeted mutation 1, Deepak Srivastava
• MGI ID: MGI:5575741
• Gene: Mir1a-1 Location: Chr2:180030841-180030917 bp, + strand Genetic Position: Chr2, 102.92 cM
• Alliance: Mir1a-1^tm1Dsr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207845
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The Pre-miRNA sequence which is about 280 bp in sizwe was replaced by a floxed PGK-neomycin resistance cassette. (J:207845)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir1a-1 Mutation: 0 strains or lines available

References

• Original: J:207845 Heidersbach A, et al., microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart. Elife. 2013;2:e01323
• All: 3 reference(s)