Tardbp^m1H
Chemically induced Allele Detail

Summary

• Symbol: Tardbp^m1H
• Name: TAR DNA binding protein; mutation 1, Harwell
• MGI ID: MGI:5575763
• Synonyms: Tardbp^Q101X
• Gene: Tardbp Location: Chr4:148696839-148711476 bp, - strand Genetic Position: Chr4, 78.77 cM
• Alliance: Tardbp^m1H page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a C to T transition in exon 3 that results in the amino acid substitution of a glutamine to Stop codon nonsense mutation (Q101X). (J:211620)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tardbp Mutation: 68 strains or lines available

References

• Original: J:211620 Ricketts T, et al., A nonsense mutation in mouse Tardbp affects TDP43 alternative splicing activity and causes limb-clasping and body tone defects. PLoS One. 2014;9(1):e85962
• All: 1 reference(s)