Errfi1^tm3.1Gvw
Targeted Allele Detail

Summary

• Symbol: Errfi1^tm3.1Gvw
• Name: ERBB receptor feedback inhibitor 1; targeted mutation 3.1, George F Vande Woude
• MGI ID: MGI:5575860
• Synonyms: Mig-6^flox
• Gene: Errfi1 Location: Chr4:150938376-150953349 bp, + strand Genetic Position: Chr4, 81.5 cM, cytoband E1
• Alliance: Errfi1^tm3.1Gvw page

Osteoarthritis-like disorder in Errfi1^tm3.1Gvw/Errfi1^tm3.1Gvw Tg(CMV-cre)1Cgn/0 knee joints

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206807
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP-FRT-Neo-FRT-exons 2 to 4-loxP cassette was inserted. FLP-mediated recombination removed the neo cassette, leaving the exons 2 to 4 flanked by loxP sites. (J:206807)

Genertion of the Errfi1^tm3.1Gvw allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Errfi1 Mutation: 18 strains or lines available

References

• Original: J:206807 Staal B, et al., Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2590-5
• All: 1 reference(s)