Deaf1^tm1.1Mico
Targeted Allele Detail

Summary

• Symbol: Deaf1^tm1.1Mico
• Name: DEAF1, transcription factor; targeted mutation 1.1, Michael Collard
• MGI ID: MGI:5576138
• Synonyms: Deaf1^2lox, Deaf1^fl
• Gene: Deaf1 Location: Chr7:140877093-140907603 bp, - strand Genetic Position: Chr7, 86.61 cM
• Alliance: Deaf1^tm1.1Mico page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211699
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in intron 1 and a floxed neo resistance cassette was inserted in intron 5. Cre excision of the resistance cassette left exons 2, 3, 4, and 5 flanked by loxP sites. (J:211699)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Deaf1 Mutation: 27 strains or lines available

References

• Original: J:211699 Vulto-van Silfhout AT, et al., Mutations affecting the SAND domain of DEAF1 cause intellectual disability with severe speech impairment and behavioral problems. Am J Hum Genet. 2014 May 1;94(5):649-61
• All: 3 reference(s)