Tg(Myh6-TNNT2*R141W)#Lian
Transgene Detail

Summary

• Symbol: Tg(Myh6-TNNT2*R141W)#Lian
• Name: transgene insertion, Zhang Lianfeng
• MGI ID: MGI:5576170
• Synonyms: cTnT^R141W
• Transgene: Tg(Myh6-TNNT2*R141W)#Lian Location: unknown
• Alliance: Tg(Myh6-TNNT2*R141W)#Lian page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-TNNT2*R141W)#Lian expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TNNT2 (7139)

  Tnnt2

  (MGI:104597)

• Mutation details: This transgene consists of the Myh6 promoter driving expression of a full-length human TNNT2 cDNA containing a T to C substitution at position 520 that results in the R141W mutation. Northern blot and immunohistochemistry confirmed expression. Three lines were established: 1, 13, and 16, however the pound symbol (#) is used because the lines are pooled. (J:211769)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Three lines were established: 1, 13, and 16.

References

• Original: J:211769 Juan F, et al., The changes of the cardiac structure and function in cTnTR141W transgenic mice. Int J Cardiol. 2008 Aug 1;128(1):83-90
• All: 7 reference(s)