Muc5b^tm1.2Evns
Targeted Allele Detail

Summary

• Symbol: Muc5b^tm1.2Evns
• Name: mucin 5, subtype B, tracheobronchial; targeted mutation 1.2, Christopher M Evans
• MGI ID: MGI:5576290
• Synonyms: Muc5b^delta
• Gene: Muc5b Location: Chr7:141392807-141426821 bp, + strand Genetic Position: Chr7, 87.29 cM, cytoband F5
• Alliance: Muc5b^tm1.2Evns page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207159
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed the floxed exon 1. Immunohistochemistry confirmed absence of protein in lungs. (J:207159)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Muc5b Mutation: 215 strains or lines available

References

• Original: J:207159 Roy MG, et al., Muc5b is required for airway defence. Nature. 2014 Jan 16;505(7483):412-6
• All: 10 reference(s)