Tg(Cd68-BCL2)535Medz
Transgene Detail

Summary

• Symbol: Tg(Cd68-BCL2)535Medz
• Name: transgene insertion 535, Ruslan Medzhitov
• MGI ID: MGI:5576381
• Synonyms: Tg(bcl2) 535rm, Tg(hbcl2)535rm
• Transgene: Tg(Cd68-BCL2)535Medz Location: unknown
• Alliance: Tg(Cd68-BCL2)535Medz page

Transgene origin

• Strain of Origin: 129 x C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene contains the promoter of the CD68 antigen gene driving expression of human B cell leukemia/lymphoma 2 (BCL2). Immunoblot analysis demonstrates expression of human BCL2 in dendritic cells (DCs) and bone-marrow derived macrophages (BMMs) of mice of this transgenic line, but not in BMMs or DCs of non-transgenic littermates. (J:211458)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

The original background of this transgene was "C57BL/6.129/Sv" (J:82809).

References

• Original: J:211458 Nogueira CV, et al., Rapid pathogen-induced apoptosis: a mechanism used by dendritic cells to limit intracellular replication of Legionella pneumophila. PLoS Pathog. 2009 Jun;5(6):e1000478
• All: 2 reference(s)