Tmbim1^tm1Noj
Targeted Allele Detail

Summary

• Symbol: Tmbim1^tm1Noj
• Name: transmembrane BAX inhibitor motif containing 1; targeted mutation 1, Hiroshi Nojima
• MGI ID: MGI:5576384
• Gene: Tmbim1 Location: Chr1:74327406-74343495 bp, - strand Genetic Position: Chr1, 38.53 cM
• Alliance: Tmbim1^tm1Noj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211693
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 1 through 6. Western blot analysis confirmed the absence of protein expression in the heart and liver. (J:211693)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tmbim1 Mutation: 30 strains or lines available

References

• Original: J:211693 Zhao H, et al., RECS1 deficiency in mice induces susceptibility to cystic medial degeneration. Genes Genet Syst. 2006 Feb;81(1):41-50
• All: 5 reference(s)