Xbp1^tm1.2Geno
Targeted Allele Detail

Summary

• Symbol: Xbp1^tm1.2Geno
• Name: X-box binding protein 1; targeted mutation 1.2, Genoway
• MGI ID: MGI:5576516
• Gene: Xbp1 Location: Chr11:5470659-5475893 bp, + strand Genetic Position: Chr11, 3.61 cM
• Alliance: Xbp1^tm1.2Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211440
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into the promoter. An FRT-flanked neomycin resistance cassette with a loxP site was inserted into intron 2. Cre-mediated recombination removed exon 1 and the selection cassette. (J:211440)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xbp1 Mutation: 29 strains or lines available

References

• Original: J:211440 Zeng L, et al., Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis. Circulation. 2013 Apr 23;127(16):1712-22
• All: 3 reference(s)