Wee2^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Wee2^em1(IMPC)J
• Name: WEE1 homolog 2 (S. pombe); endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:5576529
• Synonyms: Wee2^em1J
• Gene: Wee2 Location: Chr6:40416022-40443747 bp, + strand Genetic Position: Chr6, 18.82 cM
• Alliance: Wee2^em1(IMPC)J page
• IMPC: Wee2 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele, from project Wee2-5717J-4922, was generated by injecting Cas9 RNA and guide sequence GACTGCACAAGACATCGG into fertilized C57BL/6NJ oocytes, which resulted in an 8 bp deletion CAAGACAT in exon2 beginning at Chromosome 6 positive strand position 40444071 bp (GRCm38). It is predicted to cause a frameshift mutation with an amino acid change of glutamine to arginine after residue 31 and early truncation 13 residues later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Wee2 Mutation: 29 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)