Zap70^rps
Chemically induced Allele Detail

Summary

• Symbol: Zap70^rps
• Name: zeta-chain (TCR) associated protein kinase; reduced protein stability
• MGI ID: MGI:5576549
• Synonyms: Zap70^A243V
• Gene: Zap70 Location: Chr1:36800912-36821899 bp, + strand Genetic Position: Chr1, 15.41 cM, cytoband A4-C1
• Alliance: Zap70^rps page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a C to T point mutation that results in amino acid substitution of valine for alanine at position 243 (A243V). This mutation occures in the C-terminal SH2 domain. Flow cytometry confirmed reduced protein expression on CD4+ CD8+ T cells of the thymus and spleen. (J:211510)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zap70 Mutation: 55 strains or lines available

References

• Original: J:211510 Cauwe B, et al., A novel Zap70 mutation with reduced protein stability demonstrates the rate-limiting threshold for Zap70 in T-cell receptor signalling. Immunology. 2014 Mar;141(3):377-87
• All: 1 reference(s)