Sel1l^{tm1c(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Sel1l^{tm1c(KOMP)Wtsi}
• Name: sel-1 suppressor of lin-12-like (C. elegans); targeted mutation 1c, Welcome Trust Sanger Institute
• MGI ID: MGI:5576558
• Synonyms: Sel1L^f
• Gene: Sel1l Location: Chr12:91772817-91815931 bp, - strand Genetic Position: Chr12, 45.02 cM, cytoband E
• Alliance: Sel1l^{tm1c(KOMP)Wtsi} page
• IMPC: Sel1l gene page

Exocrine pancreatic insufficiency in Sel1l^{tm1c(KOMP)Wtsi}/Sel1l^{tm1c(KOMP)Wtsi} Tg(CAG-cre/Esr1*)5Amc/0 mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: EPD0284_3_D08
• Germline Transmission: Earliest citation of germline transmission: J:206568
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

Allele Type: Targeted (Conditional ready) Mutation: Insertion Vector: L1L2_Bact_P Flp recombinase expression excised the lacZ-neo cassette from the tm1a allele. (J:206568)

Generation of the Sel1l^tm1a(KOMP)Wtsi and Sel1l^tm1c(KOMP)Wtsi alleles

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sel1l Mutation: 34 strains or lines available

Notes

Conflicting reports exist for the integrity of the ES mutant cell line EPD0284_3_D08. A published report (J:206568) describes the line as carrying the Sel1l^{tm1a(KOMP)Wtsi} allele and the Sel1l^{tm1c(KOMP)Wtsi} allele derived from it. However, analysis at the Wellcome Trust Sanger Institute suggests that this ES cell line only carries the Sel1l^{tm1e(KOMP)Wtsi} allele.

References

• Original: J:206568 Sun S, et al., Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):E582-91
• All: 17 reference(s)