Prdm6^tm1.1Jrld
Targeted Allele Detail

Summary

• Symbol: Prdm6^tm1.1Jrld
• Name: PR domain containing 6; targeted mutation 1.1, Jurgen Ruland
• MGI ID: MGI:5576799
• Synonyms: Prdm6^flox
• Gene: Prdm6 Location: Chr18:53597027-53708976 bp, + strand Genetic Position: Chr18, 29.04 cM
• Alliance: Prdm6^tm1.1Jrld page

Massive hemorrhage in Prdm6^tm1.1Jrld/Prdm6^tm1.2Jrld; Tg(Tagln-cre)1Her lungs

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209773
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: An FRT- and loxP-flanked neomycin resistance cassette was inserted upstream of exon 3. An addtional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exon 3 floxed. (J:209773)

Generation of the Prdm6^tm1.1Jrld and Prdm6^tm1.2Jrld alleles

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prdm6 Mutation: 28 strains or lines available

References

• Original: J:209773 Gewies A, et al., Prdm6 is essential for cardiovascular development in vivo. PLoS One. 2013;8(11):e81833
• All: 3 reference(s)