Ubqln1^tm1.1Hmw
Targeted Allele Detail

Summary

• Symbol: Ubqln1^tm1.1Hmw
• Name: ubiquilin 1; targeted mutation 1.1, Hongmin Wang
• MGI ID: MGI:5576876
• Synonyms: ubqln^flox
• Gene: Ubqln1 Location: Chr13:58323970-58363467 bp, - strand Genetic Position: Chr13, 30.95 cM
• Alliance: Ubqln1^tm1.1Hmw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206930
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele contains floxed-exons 2 and 3. Removal of the floxed region causes frame shift and leads to nonsense mutation close to exon 1. An FRT flanked neo cassette used during targeting was removed by flp mediated recombination. (J:206930)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ubqln1 Mutation: 24 strains or lines available

References

• Original: J:206930 Liu Y, et al., Ubiquilin-1 protects cells from oxidative stress and ischemic stroke caused tissue injury in mice. J Neurosci. 2014 Feb 19;34(8):2813-21
• All: 1 reference(s)