Ppargc1a^tm2.1Brsp
Targeted Allele Detail

Summary

• Symbol: Ppargc1a^tm2.1Brsp
• Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; targeted mutation 2.1, Bruce M Spiegelman
• MGI ID: MGI:5576884
• Synonyms: Pgc-1alpha^fl
• Gene: Ppargc1a Location: Chr5:51611592-51725068 bp, - strand Genetic Position: Chr5, 27.02 cM, cytoband C1
• Alliance: Ppargc1a^tm2.1Brsp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208380
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 3-5 were flanked by loxP sites. A neo with a third loxP site was located downstream of the floxed exons. Cre-mediated recombination removed the selection cassette. (J:208380)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ppargc1a Mutation: 48 strains or lines available

References

• Original: J:208380 Sczelecki S, et al., Loss of Pgc-1alpha expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation. Am J Physiol Endocrinol Metab. 2014 Jan 15;306(2):E157-67
• All: 42 reference(s)