Ryr2^tm1Krbr
Targeted Allele Detail

Summary

• Symbol: Ryr2^tm1Krbr
• Name: ryanodine receptor 2, cardiac; targeted mutation 1, Kenneth R Boheler
• MGI ID: MGI:5576915
• Synonyms: Ryr2^flox
• Gene: Ryr2 Location: Chr13:11567988-12121831 bp, - strand Genetic Position: Chr13, 4.38 cM, cytoband A1-A2
• Alliance: Ryr2^tm1Krbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210083
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 20. An additional loxP site was inserted downstream of exon 20. Previously, it was reported that exon 3 was floxed in this strain. More recent data has now suggested that exon 20 is floxed. (J:77723)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ryr2 Mutation: 325 strains or lines available

References

• Original: J:210083 Bround MJ, et al., Cardiac ryanodine receptors control heart rate and rhythmicity in adult mice. Cardiovasc Res. 2012 Dec 1;96(3):372-80
• All: 9 reference(s)