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Hprt1tm4(CAG-Tbx18*,-Venus)Akis
Targeted Allele Detail
Summary
Symbol: Hprt1tm4(CAG-Tbx18*,-Venus)Akis
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 4, Andreas Kispert
MGI ID: MGI:5576943
Synonyms: HprtTbx18VP16
Gene: Hprt1  Location: ChrX:52077014-52110536 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Alliance: Hprt1tm4(CAG-Tbx18*,-Venus)Akis page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:210076
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Hprt1tm4(CAG-Tbx18*,-Venus)Akis expresses 1 gene
 
Mutation detailsThe targeting construct inserted into the locus a CAG promoter, loxP site, neomycin resistance/STOP cassette, loxM site, and in an inverted cassette containing loxP and loxM sites, Tbx18 cDNA with a VP16 activator, IRES, Venus reporter sequence and polyadenylation sequence. Cre-mediated recombination is required to achieve expression of the inverted cassette. (J:210076)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hprt1 Mutation:  1279 strains or lines available
References
Original:  J:210076 Greulich F, et al., Tbx18 function in epicardial development. Cardiovasc Res. 2012 Dec 1;96(3):476-83
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory