About   Help   FAQ
Hprt1tm4(CAG-Tbx18*,-Venus)Akis
Targeted Allele Detail
Summary
Symbol: Hprt1tm4(CAG-Tbx18*,-Venus)Akis
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 4, Andreas Kispert
MGI ID: MGI:5576943
Synonyms: HprtTbx18VP16
Gene: Hprt1  Location: ChrX:52077014-52110536 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Alliance: Hprt1tm4(CAG-Tbx18*,-Venus)Akis page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:210076
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Hprt1tm4(CAG-Tbx18*,-Venus)Akis expresses 1 gene
 
Mutation detailsThe targeting construct inserted into the locus a CAG promoter, loxP site, neomycin resistance/STOP cassette, loxM site, and in an inverted cassette containing loxP and loxM sites, Tbx18 cDNA with a VP16 activator, IRES, Venus reporter sequence and polyadenylation sequence. Cre-mediated recombination is required to achieve expression of the inverted cassette. (J:210076)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hprt1 Mutation:  1279 strains or lines available
References
Original:  J:210076 Greulich F, et al., Tbx18 function in epicardial development. Cardiovasc Res. 2012 Dec 1;96(3):476-83
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory