Map3k7^tm1.2Gkl
Targeted Allele Detail

Summary

• Symbol: Map3k7^tm1.2Gkl
• Name: mitogen-activated protein kinase kinase kinase 7; targeted mutation 1.2, George Kollias
• MGI ID: MGI:5576980
• Gene: Map3k7 Location: Chr4:31964097-32023467 bp, + strand Genetic Position: Chr4, 13.91 cM
• Alliance: Map3k7^tm1.2Gkl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211916
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 2, which encodes part of the kinase domain including the ATP binding pocket. (J:211916)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Map3k7 Mutation: 54 strains or lines available

References

• Original: J:211916 Eftychi C, et al., Myeloid TAKI [corrected] acts as a negative regulator of the LPS response and mediates resistance to endotoxemia. PLoS One. 2012;7(2):e31550
• All: 1 reference(s)