Mc1r^E-So4J
Spontaneous Allele Detail

Summary

• Symbol: Mc1r^E-So4J
• Name: melanocortin 1 receptor; sombre 4 Jackson
• MGI ID: MGI:5577146
• Gene: Mc1r Location: Chr8:124133846-124137483 bp, + strand Genetic Position: Chr8, 72.1 cM
• Alliance: Mc1r^E-So4J page

Mc1r^E-So4J/Mc1r⁺ on the left showing darkened tail and ears compared to wild-type sibling on the right

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: B6.129S7-Ldlr^tm1Her/J

Mutation description

• Allele Type: Spontaneous (Constitutively active)
• Mutation: Single point mutation
• Mutation details: A spontaneous G-to-A change at chromosome 8 position 123,407,783 (GRCm38) results in the missense mutation p.E92K. (J:222308)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mc1r Mutation: 44 strains or lines available

References

• Original: J:230486 Harris BS, et al., The sombre 4 Jackson mutation. MGI Direct Data Submission. 2016
• All: 2 reference(s)