Mybl2^tm1.1Epr
Targeted Allele Detail

Summary

• Symbol: Mybl2^tm1.1Epr
• Name: myeloblastosis oncogene-like 2; targeted mutation 1.1, E Premkumar Reddy
• MGI ID: MGI:5577181
• Synonyms: B-myb^F
• Gene: Mybl2 Location: Chr2:162896607-162926608 bp, + strand Genetic Position: Chr2, 84.0 cM
• Alliance: Mybl2^tm1.1Epr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206816
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP-flanked neo cassette was inserted at 5' of exon 6 and a third loxP sequence downstream of exon 6. Cre mediated recombination removed the neo cassette, creating an allele with exon 6 flanked by loxP sites. (J:206816)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mybl2 Mutation: 114 strains or lines available

References

• Original: J:206816 Baker SJ, et al., B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3122-7
• All: 1 reference(s)