Traf3^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Traf3^m1Btlr
• Name: TNF receptor-associated factor 3; mutation 1, Bruce Beutler
• MGI ID: MGI:5578024
• Synonyms: hulk
• Gene: Traf3 Location: Chr12:111132804-111233587 bp, + strand Genetic Position: Chr12, 60.94 cM, cytoband F
• Alliance: Traf3^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to A transversion at base pair 111,261,576 (v38) on Chromosome 12, or base pair 95,207 in the GenBank genomic region NC_000078. The mutation corresponds to residue 1,395 in the mRNA sequence NM_001286122 within exon 12 of 12 total exons (isoform 1) and residue 1,581 in the mRNA sequence NM_011632 within exon 10 of 10 total exons (isoform 2). The mutation results in an valine (V) to aspartic acid (D) substitution at position 407 (V407D) in the ENSMUSP00000021706 isoform and a V to D substitution at position 382 (V382D) in the ENSMUSP00000112517 isoform. (J:212064)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Traf3 Mutation: 42 strains or lines available

References

• Original: J:212064 Wang K-W, et al., Mutagenetix entry for hulk. MGI Direct Data Submission. 2014
• All: 1 reference(s)