Tbc1d10c^tm1.1Psou
Targeted Allele Detail

Summary

• Symbol: Tbc1d10c^tm1.1Psou
• Name: TBC1 domain family, member 10c; targeted mutation 1.1, Pauline Soulas-Sprauel
• MGI ID: MGI:5578033
• Synonyms: Carabin^f
• Gene: Tbc1d10c Location: Chr19:4234356-4241194 bp, - strand Genetic Position: Chr19, 3.88 cM
• Alliance: Tbc1d10c^tm1.1Psou page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211913
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4. A floxed neomycin resistance cassette was inserted downstream of exon 5. Cre-mediated recombination removed the selection cassette and left exons 4 and 5 floxed. (J:211913)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tbc1d10c Mutation: 19 strains or lines available

References

• Original: J:211913 Schickel JN, et al., Carabin deficiency in B cells increases BCR-TLR9 costimulation-induced autoimmunity. EMBO Mol Med. 2012 Dec;4(12):1261-75
• All: 1 reference(s)