Tg(Alb-PDGFC)#Jcam
Transgene Detail

Summary

• Symbol: Tg(Alb-PDGFC)#Jcam
• Name: transgene insertion, Jean S Campbell
• MGI ID: MGI:5578131
• Synonyms: PDGF-C Tg
• Transgene: Tg(Alb-PDGFC)#Jcam Location: unknown
• Alliance: Tg(Alb-PDGFC)#Jcam page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Alb-PDGFC)#Jcam expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PDGFC (56034)

  Pdgfc

  (MGI:1859631)

• Mutation details: This transgene consists of a 1,058-bp fragment containing the human PDGFC open reading frame between the mouse albumin enhancer/proximal promoter with an adjacent 5' rat insulin II intron and a human growth hormone polyadenylation sequence. Human PDGFC expression in the liver was detected only in one line, however, the pound symbol (#) is used because the line number is not specified. (J:96979)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:96979 Campbell JS, et al., Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3389-94
• All: 4 reference(s)