Cgastm1d(EUCOMM)Hmgu
Targeted Allele Detail
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Symbol: |
Cgastm1d(EUCOMM)Hmgu |
Name: |
cyclic GMP-AMP synthase; targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH |
MGI ID: |
MGI:5578170 |
Synonyms: |
cGAS, Mb21d1- |
Gene: |
Cgas Location: Chr9:78337808-78350519 bp, - strand Genetic Position: Chr9, 43.65 cM
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Alliance: |
Cgastm1d(EUCOMM)Hmgu page
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IMPC: |
Cgas gene page |
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Mutant Cell Line: |
HEPD0516_3_C04 |
Germline Transmission: |
Earliest citation of germline transmission:
J:207826
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Parent Cell Line: |
JM8.N4 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 78344357 of Chromosome 9 upstream of the critical exon 2 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 2 at position 78345237. The critical exon 2 is thus flanked by loxP sites. Flp-mediated recombination removed the beta-geo cassette and left exon 2 floxed. Cre-mediated recombination removed exon 2. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml.
(J:207826)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:207826 Schoggins JW, et al., Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature. 2014 Jan 30;505(7485):691-5 |
All: |
125 reference(s) |
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