Acadvl^tm1Zkhu
Targeted Allele Detail

Summary

• Symbol: Acadvl^tm1Zkhu
• Name: acyl-Coenzyme A dehydrogenase, very long chain; targeted mutation 1, Zaza Khuchua
• MGI ID: MGI:5578174
• Synonyms: VLCAD^flx
• Gene: Acadvl Location: Chr11:69901009-69906237 bp, - strand Genetic Position: Chr11, 42.96 cM, cytoband B2-B5
• Alliance: Acadvl^tm1Zkhu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208711
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. (J:208711)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Acadvl Mutation: 31 strains or lines available

References

• Original: J:208711 Xiong D, et al., Cardiac-specific VLCAD deficiency induces dilated cardiomyopathy and cold intolerance. Am J Physiol Heart Circ Physiol. 2014 Feb;306(3):H326-38
• All: 1 reference(s)