Stat4^ity14
Chemically induced Allele Detail

Summary

• Symbol: Stat4^ity14
• Name: signal transducer and activator of transcription 4; immunity to Typhimurium locus 14
• MGI ID: MGI:5578183
• Gene: Stat4 Location: Chr1:52026307-52146348 bp, + strand Genetic Position: Chr1, 26.67 cM
• Alliance: Stat4^ity14 page

Mutation origin

• Strain of Origin: 129S1/Sv

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU-mutagenesis induced a G to A point mutation in the splice donor site of exon 15 that results in a 28 amino acid deletion in the DNA binding domain. (J:207092)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stat4 Mutation: 64 strains or lines available

References

• Original: J:207092 Eva MM, et al., Altered IFN-gamma-mediated immunity and transcriptional expression patterns in N-Ethyl-N-nitrosourea-induced STAT4 mutants confer susceptibility to acute typhoid-like disease. J Immunol. 2014 Jan 1;192(1):259-70
• All: 2 reference(s)