Tg(Prnp-MAPT*)2652Gds
Transgene Detail

Summary

• Symbol: Tg(Prnp-MAPT*)2652Gds
• Name: transgene insertion 2652, Gerard Schellenberg
• MGI ID: MGI:5578354
• Synonyms: Tau4RTg2652, Tg2652, Tg(pThy1.2-MAPT*)2652Gsd, Tg(Thy1-MAPT*)2652Gds
• Transgene: Tg(Prnp-MAPT*)2652Gds Location: unknown
• Alliance: Tg(Prnp-MAPT*)2652Gds page

Transgene origin

• Strain of Origin: (C57BL/6J x C3H/HeJ)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-MAPT*)2652Gds expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: The 1N4R brain isoform of human MAPT (microtubule associated protein, tau) is expressed under the control of the mouse neuron-specific prion protein (PrP) promoter. Hemizygous mice exhibit approximate 12-fold overexpression of human tau relative to endogenous mouse tau and show consistent transmission of approximately 143+/-20 copies of the transgene. (J:94077, J:244052)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
Loading...
tg1	Tg(Prnp-MAPT*)2652Gds/Tg(Prnp-MAPT*)2652Gds	B6.Cg-Tg(Prnp-MAPT*)2652Gds
tg2  Disease Model	Tg(Prnp-MAPT*)2652Gds/0	B6.Cg-Tg(Prnp-MAPT*)2652Gds

Phenotypes:

Affected Systems	tg1	tg2
show or hide all annotated terms Sex:
behavior/neurological	√	√	√
abnormal behavior		√	√
abnormal spatial reference memory		√	√
impaired coordination		√	√
decreased grip strength		√	√
abnormal locomotor behavior	√
decreased vertical activity			√
decreased locomotor activity			√
seizures	√
growth/size/body	√	√	√
decreased body weight	√	√	√
mortality/aging	√
premature death	√
muscle		√	√
skeletal muscle fiber atrophy		√	√
nervous system	√	√	√
seizures	√
tau protein deposits		√	√
abnormal neurite morphology		√	√
axonal spheroids		√	√
reproductive system	√
reduced fertility	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	tg2
tauopathy IDs tauopathy       DOID:680 MESH:D024801 UMLS_CUI:C0949664 Close	√

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 3 reference(s)