Myo10^m1J
Spontaneous Allele Detail

Summary

• Symbol: Myo10^m1J
• Name: myosin X; mutation 1 Jackson
• MGI ID: MGI:5578506
• Gene: Myo10 Location: Chr15:25622636-25813759 bp, + strand Genetic Position: Chr15, 9.36 cM, cytoband C
• Alliance: Myo10^m1J page

Mutation origin

• Strain of Origin: B6.129S2-Cd4^tm1Mak/J

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This is a spontaneous eight nucleotide (CGACGAGT) deletion at chromosome 15 position 25,781,267-274 bp (GRCm38). The deletion disrupts exon 25 and produces a frame shift expected to truncate the full-length and all three headless transcripts following aa 948. Immunoblot of whole brain lysates from 1-month-old mutant mice revealed combined deletion of the full-length and headless forms, confirming complete loss of encoded protein. (J:222308, J:256438)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	10 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myo10 Mutation: 612 strains or lines available

References

• Original: J:214794 Karst SY, et al., A spontaneous mutation in mouse Myo10. MGI Direct Data Submission. 2014
• All: 6 reference(s)