Tmprss2^{tm1.1(ERG)Sho}
Targeted Allele Detail

Summary

• Symbol: Tmprss2^{tm1.1(ERG)Sho}
• Name: transmembrane protease, serine 2; targeted mutation 1.1, Stuart Orkin
• MGI ID: MGI:5578606
• Synonyms: T-ERG, Tmprss2-ERG, Tmprss2-hERG
• Gene: Tmprss2 Location: Chr16:97365882-97412395 bp, - strand Genetic Position: Chr16, 57.53 cM, cytoband C2
• Alliance: Tmprss2^{tm1.1(ERG)Sho} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212219
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a floxed neomycin resistance cassette, stopper cassette, loxP site, human cDNA for ERG lacking the N-terminus encoding sequence, IRES, GFP and polyadenylation sequence. Cre-mediated recombination removed the selection and stopper cassettes to achieve expression of the fusion product and reporter. (J:212219)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmprss2 Mutation: 55 strains or lines available

References

• Original: J:212219 Baena E, et al., ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. Genes Dev. 2013 Mar 15;27(6):683-98
• All: 5 reference(s)