Tmprss2tm1.1(ERG)Sho
Targeted Allele Detail
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Symbol: |
Tmprss2tm1.1(ERG)Sho |
Name: |
transmembrane protease, serine 2; targeted mutation 1.1, Stuart Orkin |
MGI ID: |
MGI:5578606 |
Synonyms: |
T-ERG, Tmprss2-ERG, Tmprss2-hERG |
Gene: |
Tmprss2 Location: Chr16:97365882-97412395 bp, - strand Genetic Position: Chr16, 57.53 cM, cytoband C2
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Alliance: |
Tmprss2tm1.1(ERG)Sho page
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Germline Transmission: |
Earliest citation of germline transmission:
J:212219
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 2 was replaced with a floxed neomycin resistance cassette, stopper cassette, loxP site, human cDNA for ERG lacking the N-terminus encoding sequence, IRES, GFP and polyadenylation sequence. Cre-mediated recombination removed the selection and stopper cassettes to achieve expression of the fusion product and reporter.
(J:212219)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tmprss2 Mutation: |
53 strains or lines available
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Original: |
J:212219 Baena E, et al., ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. Genes Dev. 2013 Mar 15;27(6):683-98 |
All: |
5 reference(s) |
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