Del(16Tmprss2-Erg)1Sho
Targeted Allele Detail

Summary

• Symbol: Del(16Tmprss2-Erg)1Sho
• Name: deletion, Chr 16, Stuart Orkin 1
• MGI ID: MGI:5578624
• Synonyms: Del1Sho, T-delta-Erg
• Gene: Del(16Tmprss2-Erg)1Sho Location: unknown Genetic Position: Chr16, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212219
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(16Tmprss2-Erg)1Sho involves 29 genes/genome features (Gm24777, Gm15317, Gm15341 ...) View all
• Mutation details: Cre-mediated recombination between Erg^tm1.1Sho and Tmprss2^tm3Sho results in a 3 MB deletion and creates a fusion product between the end points that recapitulates a gene fusion frequently observed in patients with prostate cancer. (J:212219)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(16Tmprss2-Erg)1Sho Mutation: 0 strains or lines available

References

• Original: J:212219 Baena E, et al., ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. Genes Dev. 2013 Mar 15;27(6):683-98
• All: 2 reference(s)