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Myo1gtm1.2Mfk
Targeted Allele Detail
Summary
Symbol: Myo1gtm1.2Mfk
Name: myosin IG; targeted mutation 1.2, Matthew F Krummel
MGI ID: MGI:5581464
Gene: Myo1g  Location: Chr11:6456548-6470960 bp, - strand  Genetic Position: Chr11, 4.3 cM, cytoband A1
Alliance: Myo1gtm1.2Mfk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:209304
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 2 and 3. Western blot analysis confirmed the absence of protein expression in spleen cells. (J:212451)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myo1g Mutation:  53 strains or lines available
References
Original:  J:209304 Maravillas-Montero JL, et al., Myosin 1g regulates cytoskeleton plasticity, cell migration, exocytosis, and endocytosis in B lymphocytes. Eur J Immunol. 2014 Mar;44(3):877-86
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory