Myo1g^tm1.2Mfk
Targeted Allele Detail

Summary

• Symbol: Myo1g^tm1.2Mfk
• Name: myosin IG; targeted mutation 1.2, Matthew F Krummel
• MGI ID: MGI:5581464
• Gene: Myo1g Location: Chr11:6456548-6470960 bp, - strand Genetic Position: Chr11, 4.3 cM, cytoband A1
• Alliance: Myo1g^tm1.2Mfk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209304
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 2 and 3. Western blot analysis confirmed the absence of protein expression in spleen cells. (J:212451)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myo1g Mutation: 53 strains or lines available

References

• Original: J:209304 Maravillas-Montero JL, et al., Myosin 1g regulates cytoskeleton plasticity, cell migration, exocytosis, and endocytosis in B lymphocytes. Eur J Immunol. 2014 Mar;44(3):877-86
• All: 4 reference(s)