Cables1^tm1Utr
Targeted Allele Detail

Summary

• Symbol: Cables1^tm1Utr
• Name: CDK5 and Abl enzyme substrate 1; targeted mutation 1, University of Tsukuba Laboratory Animal Resource Center
• MGI ID: MGI:5581469
• Synonyms: Cables1^null
• Gene: Cables1 Location: Chr18:11972600-12078681 bp, + strand Genetic Position: Chr18, 5.88 cM, cytoband A2
• Alliance: Cables1^tm1Utr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206297
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced by a neomycin resistance gene cassette. RT-PCR with primers spanning from exon 2 through exon 7 demonstrated the absence of both isoform I and isoform II mRNA in homozygous mice. (J:206297)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cables1 Mutation: 40 strains or lines available

References

• Original: J:206297 Mizuno S, et al., Truncated Cables1 causes agenesis of the corpus callosum in mice. Lab Invest. 2014 Mar;94(3):321-30
• All: 1 reference(s)