Kel^tm1Slee
Targeted Allele Detail

Summary

• Symbol: Kel^tm1Slee
• Name: Kell blood group; targeted mutation 1, Soohee Lee
• MGI ID: MGI:5581644
• Gene: Kel Location: Chr6:41663263-41681268 bp, - strand Genetic Position: Chr6, 19.86 cM
• Alliance: Kel^tm1Slee page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212529
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A 3.2 kb segment spanning from the start of exon 11 into exon 16. This region includes the zinc binding enzymatically active site was reolaced with a neomycin resistance gene. Northern blot analysis confirmed the absence of mRNA and Western blot analysis demonstrated the absence of protein on RBC membranes. (J:212529)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kel Mutation: 44 strains or lines available

References

• Original: J:212529 Zhu X, et al., Changes in red cell ion transport, reduced intratumoral neovascularization, and some mild motor function abnormalities accompany targeted disruption of the Mouse Kell gene (Kel). Am J Hematol. 2009 Aug;84(8):492-8
• All: 3 reference(s)