Mafb^tm1.2Good
Targeted Allele Detail

Summary

• Symbol: Mafb^tm1.2Good
• Name: MAF bZIP transcription factor B; targeted mutation 1.2, Lisa Goodrich
• MGI ID: MGI:5581668
• Gene: Mafb Location: Chr2:160205623-160208985 bp, - strand Genetic Position: Chr2, 80.92 cM
• Alliance: Mafb^tm1.2Good page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207904
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The single coding exon was flanked with loxP sites. An FRT-flanked neomycin resistance cassette was inserted downstream of the coding exon. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed the coding exon. Western blot analysis confirmed the absence of protein expression in E16.5 embryos. (J:207904)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mafb Mutation: 20 strains or lines available

References

• Original: J:207904 Yu WM, et al., A Gata3-Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing. Elife. 2013;2:e01341
• All: 2 reference(s)