Ncoa5^tm1Hxia
Targeted Allele Detail

Summary

• Symbol: Ncoa5^tm1Hxia
• Name: nuclear receptor coactivator 5; targeted mutation 1, Hua Xiao
• MGI ID: MGI:5581698
• Gene: Ncoa5 Location: Chr2:164842277-164876787 bp, - strand Genetic Position: Chr2, 85.32 cM
• Alliance: Ncoa5^tm1Hxia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207622
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 3 and 4. Western blot analysis confirmed a 50% reduction in protein expression in liver tissue from heterozygous mice. (J:207622)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncoa5 Mutation: 55 strains or lines available

References

• Original: J:207622 Gao S, et al., NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma. Cancer Cell. 2013 Dec 9;24(6):725-37
• All: 4 reference(s)