Gt(ROSA)26Sor^tm1(Gck)Ydor
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1(Gck)Ydor
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Yuval Dor
• MGI ID: MGI:5581726
• Synonyms: mutGCK
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1(Gck)Ydor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210493
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Constitutively active, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^tm1(Gck)Ydor expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Gck (24385)

  Gck	(MGI:1270854)

• Mutation details: The trgeting construct introduced into the locus a floxed STOP cassette, a rat cDNA with an activating amino acid substitution of cysteine for tyrosine at position 214 (Y214C), an IRES sequence and an EGFP reporter. (J:210493)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:210493 Tornovsky-Babeay S, et al., Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in beta cells. Cell Metab. 2014 Jan 7;19(1):109-21
• All: 1 reference(s)