Tg(Cryaa-APEH)KKS4Kksha
Transgene Detail

Summary

• Symbol: Tg(Cryaa-APEH)KKS4Kksha
• Name: transgene insertion KKS4, K Krishna Sharma
• MGI ID: MGI:5582277
• Transgene: Tg(Cryaa-APEH)KKS4Kksha Location: unknown
• Alliance: Tg(Cryaa-APEH)KKS4Kksha page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Cryaa-APEH)KKS4Kksha expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  pig, domestic	APEH (396961)

• Mutation details: The porcine liver APEH cDNA with an N-terminal T7 tag and C-terminal His tag is under the control of the lens specific chick delta1-crystallin enhancer and alpha-crystallin promoter. This enhancer/promoter directs transgene expression in lens epithelial and fiber cells. Seven lines were established (KKS1, KKS2, KKS3, KKS4, KKS5, KKS6, KKS7). Line KKS4 is entered as a representative line as it is the high expressing line. (J:212432)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:212432 Santhoshkumar P, et al., Lens crystallin modifications and cataract in transgenic mice overexpressing acylpeptide hydrolase. J Biol Chem. 2014 Mar 28;289(13):9039-52
• All: 1 reference(s)